Cancer Cells that Survive Radiation Lobectomy Display Markers of Increased Tumor Aggressiveness
نویسندگان
چکیده
Introduction: Radiation lobectomy (RL) is defined as the transarterial administration of high-dose radioactive microspheres to liver malignancies with intent inducing ipsilateral tumor ablation and contralateral hypertrophy. The biological characteristics therapy surviving cells their microenvironment remain unstudied. Methods: Fourteen patients received RL, which colorectal metastasis group (n = 5 90Y, n 2 166H-microspheres) analyzed here. All metastases 27) were selected from surgical pathology files. H&E IHC stains markers Ki67, CAIX, Olfm4 CD45 performed. A machine learning scoring protocol was established classify non-tumor allow unbiased quantification staining intensities (Fig. 1A). Mandard regression grades scored 1B) matched tumor-absorbed dose determined on post-treatment PET/CT. Results: Metastases that at least 60 Gy (90Y) regressed robustly, while lower portended variable response 1C). Dose positively correlated hypoxia proliferation, negatively stem cell-ness cellular immune infiltrates. Perinecrotic highly hypoxic cell-like, but not proliferative 1D). Non-responsive lesions (regression grade 5) contained large numbers cancer Conclusion: Tumor-absorbed an important determinant response, radiation-induced may lead aggressive behavior. These data augment our understanding (non) radio-responsiveness aid further evolution RL in combination strategies aimed curing hepatic malignancies.
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ژورنال
عنوان ژورنال: Hpb
سال: 2022
ISSN: ['1365-182X', '1477-2574']
DOI: https://doi.org/10.1016/j.hpb.2022.05.177